多年来,双侧肾上腺全切除术是 Cushing 氏病的唯一疗法,不仅疗效欠佳,而且使病人付出终身替代治疗的沉重代价。嗣后,化学性肾上腺切除术诸如人工合成抗皮质素 Op’DDD 疗法使63%免于肾上腺手术之苦,如辅以钴~(60)放疗不仅提高疗效且可避免 Nelson 综合征之发生。然钴~(60)有招致脑卒中和脑 Over the years, bilateral total adrenalectomy has been the only treatment for Cushing’s disease, which is not only unsatisfactory, but also costs the patient a life-long alternative to treatment. Later, chemical adrenalectomy such as synthetic anti-corticosteroid Op’DDD therapy is 63% exempt from adrenal surgery. Co-60 radiation therapy not only improves the efficacy but also avoids the occurrence of Nelson syndrome. However, cobalt 60 induces stroke and brain