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目的:探讨2型糖尿病(T2DM)性眼肌麻痹(OMP)患者血糖、糖化血红蛋白(HbA1c)与血液流变学改变之间的关系。方法:对健康对照(HC)组48例、单纯T2DM组48例和T2DM+OMP组48例共144例研究对象进行隔夜空腹12 h血HbA1c、空腹血糖(FBG)、餐后2 h血糖(2 h-PG)及血液流变学检测,并进行相关性分析。结果:T2DM+OMP组除红细胞变形指数显著低于T2DM及HC组(P<0.01)外,HbA1c、FBG、2 h-PG及其他血液流变学指标均显著高于T2DM及HC组(均P<0.01);T2DM+OMP组红细胞变形指数与FBG、HbA1c呈负相关(r=-0.56、r=-0.81,P<0.01),全血黏度(低、中、高切)、血浆黏度、纤维蛋白原与血糖、HbA1c呈正相关(r介于0.35～0.88之间,P<0.05)。结论:高血糖、高黏血症是T2DM并发周围神经病变的危险因素,控制血糖、改善微循环对预防和治疗DM并发周围神经病变有指导意义。
Objective: To investigate the relationship between blood glucose, glycosylated hemoglobin (HbA1c) and hemorheological changes in patients with type 2 diabetes (T2DM) ophthalmoplegia (OMP). Methods: Forty-eight healthy subjects (HC group), 48 cases of T2DM group (48 cases) and T2DM + OMP group (48 cases) were enrolled in this study. Blood overnight fasting HbA1c, fasting blood glucose (FBG), postprandial blood glucose h-PG) and hemorheological tests, and correlation analysis. Results: The indexes of hemorheology of HbA1c, FBG, 2 h-PG and other hemorheological indexes in T2DM + OMP group were significantly higher than those in T2DM group and HC group (P < <0.01). The index of erythrocyte degeneration in T2DM + OMP group was negatively correlated with FBG and HbA1c (r = -0.56, r = -0.81, P <0.01) Prokaryotic and blood glucose, HbA1c was positively correlated (r between 0.35 ~ 0.88, P <0.05). CONCLUSION: Hyperglycemia and hyperviscosity are risk factors of peripheral neuropathy in T2DM. Controlling blood glucose and improving microcirculation are instructive in the prevention and treatment of peripheral neuropathy.