论文部分内容阅读
VEGF是 1989年 Ferrara等在牛垂体滤泡星状细胞体外培养液中首先纯化出来的蛋白质 [1 ] ,它是血管内皮细胞的特异性有丝分裂原 ,也是一种有效的血管形成和血管通透性诱导因子 [2 ]。 VEGF存在于多种动物和人的肿瘤组织和肿瘤细胞株中 ,它在骨肿瘤中表达及其意义也受到了日益广
VEGF is the first purified protein from bovine pituitary somatic stellate cells cultured in vitro by Ferrara et al [1] in 1989. It is a specific mitogen of vascular endothelial cells and is also an effective angiogenesis and vascular permeability Inducible factor [2]. VEGF is present in a variety of animal and human tumor tissues and tumor cell lines, and its expression in bone tumors and its significance have also been increasingly widespread