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血小板抑制剂对动脉粥样硬化,尤其是急性局部缺血综合症如不稳定型心绞痛和心肌梗塞等的治疗是有益的。阿斯匹林作为一种血小板抑制剂能抑制环加氧酶(Cyclooxygenase),延长出血时间和减少血小板聚集,在临床已广泛应用,本研究的目的是通过对脂类喂养的兔子使用不同剂量的阿斯匹林,观察其出血时间、血小板聚集和粥样硬化的发生,以评价阿斯匹林的剂量和效应的关系。方法:48只雄性新西兰白兔分为5组(对照组C和治疗组A_1、A_(10)、A_(30)、A_(60)),用高胆固醇喂养12周。
Platelet inhibitors are beneficial for the treatment of atherosclerosis, especially acute ischemic syndromes such as unstable angina pectoris and myocardial infarction. As a platelet inhibitor aspirin can inhibit cyclooxygenase (Cyclooxygenase), prolong bleeding time and reduce platelet aggregation, has been widely used in clinical, the purpose of this study is to rabbits fed with lipid-different doses of Aspirin, observed bleeding time, platelet aggregation and atherosclerosis in order to evaluate the relationship between aspirin dose and effect. Methods: Forty eight male New Zealand white rabbits were divided into five groups (control group C and treatment group A_1, A_ (10), A_ (30), A_ (60)) and fed with high cholesterol for 12 weeks.