甘露醇脱水迅速、效力可靠,为降低颅内压首选药物,且该药不良反应轻微,罕有引起严重反应者。而我们遇及4例小儿静滴该药后出现严重反应,现报告如下,以引起同道之警惕。例1,男,7岁,因发热、头痛及呕吐2天伴嗜睡半天,于1986年3月6日入院。患儿经临床检查诊断为暴发性流脑(败血症型)合并左下肺炎,而给予抗感染、抗休克治疗,及每8小时1次常规量甘露醇加压静滴以降低颅内压。经过上述治疗后患儿病情逐渐好转,但次日在第四次给予甘露醇后患儿突然心跳呼吸停止,全身发绀,而遂即给予胸外心脏按压、吸氧及静注可拉明0.375g,5分钟后 Mannitol rapid dehydration, efficacy and reliable, in order to reduce the preferred drug intracranial pressure, and the drug mild adverse reactions, rare cause serious reactions. We encountered four cases of pediatric intravenous infusion of this drug after a serious reaction, are as follows, in order to arouse the vigilance of fellow. Example 1, male, 7 years old, admitted to hospital on March 6, 1986 due to fever, headache and vomiting for 2 days with lethargy for half a day. Children diagnosed with fulminant meningitis (sepsis type) with left lower pneumonia by clinical examination were given anti-infective, anti-shock treatment and intravenous infusion of mannitol once every 8 hours to reduce intracranial pressure. After the treatment of children with the condition gradually improved, but the fourth day after the fourth mannitol in children with sudden heartbeat stopped breathing, systemic cyanosis, and then give the chest heart pressure, oxygen and intravenous injection of cocaine 0.375g ,5 minutes later