查阅国内外有关非典型抗精神病药物与体重增加的临床试验资料和文献,并进行整理、分析。结果发现,非典型抗精神病药物氯氮平、奥氮平、奎硫平、左替平、利培酮均不同程度地引起体重增加,而齐哌西酮对体重的影响较小;体重增加一般发生于用药6～12周。本文对非典型抗精神病药物致体重增加的药理学机制及药物的顺应性等问题进行介绍。 Access to domestic and foreign clinical trials on atypical antipsychotic drugs and weight gain information and literature, and organize, analyze. The results showed that the atypical antipsychotics clozapine, olanzapine, quetiapine, levodipine and risperidone all caused different degrees of weight gain, while the effect of piperidone on body weight was less; Occurs in the medication 6 to 12 weeks. This article describes the atypical antipsychotic induced weight gain pharmacological mechanisms and drug compliance issues.