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[目的]通过环境流行病学调查,研究镉性肾损伤健康风险评价中尿镉与尿β2-微球蛋白、尿NAG酶间的剂量-反应关系及其相应的基准剂量,并通过基准剂量的比较确定敏感指标。[方法]选择黄石市某有色冶炼厂周边镉污染区居民为接触组,非污染区居民为对照组。尿镉为镉性肾损伤的内暴露指标,尿β2-微球蛋白、尿NAG酶为效应指标,均用尿肌酐校正。[结果]尿镉与尿β2-微球蛋白、尿NAG酶间存在明显的剂量-反应关系,尿NAG酶对应尿镉BMDL值(1.117μg/g.cr)大于尿β2-微球蛋白对应尿镉BMDL值(0.623μg/g.cr)。[结论]镉性肾损伤主要表现为肾小管损害,尿β2-微球蛋白是该污染区镉性肾损伤健康风险评价的相对敏感的指标。
[Objective] To investigate the dose-response relationship between urinary cadmium and urinary β2-microglobulin and urinary NAG in health risk assessment of cadmium-induced renal injury and its corresponding baseline dose through environmental epidemiological investigation. More sensitive indicators. [Method] The residents in the cadmium polluted area around a colored smelter in Huangshi City were selected as the contact group and the non-polluted area residents as the control group. Urinary cadmium is an indicator of cadmium exposure of renal injury, urine β2-microglobulin, urinary NAG enzyme as an effect index, were corrected with urinary creatinine. [Results] There was a significant dose-response relationship between urinary cadmium and urinary β2-microglobulin and urinary NAG enzyme. The urinary NAG enzyme corresponding urinary cadmium BMDL value (1.117μg / g.cr) was greater than urinary β2-microglobulin corresponding urine Cadmium BMDL value (0.623 μg / g.cr). [Conclusion] The main manifestation of cadmium-induced renal injury is tubulointerstitial damage. Urine β2-microglobulin is a relatively sensitive index for evaluating the health risk of cadmium-induced renal injury in this polluted area.