双氯灭痛为非甾体抗炎药,有良好的抗炎镇痛作用,国内外对其剂型的开发研究很活跃,其中双氯灭痛凝胶剂已由Ciba—Ceigy公司投入市场。据报道,因其透皮吸收好,可较迅速地缓解局部或全身炎症及疼痛,且由于是皮肤用药,所以能较持久地发挥治疗作用而又避免了胃肠道刺激。在国内,山东省医药工业研究所研制出双氯灭痛凝胶软膏,本文报道了其对动物抗炎镇痛作用的研究。 Diclofenac is a non-steroidal anti-inflammatory drug and has good anti-inflammatory and analgesic effects. Research and development of its dosage form is very active at home and abroad. Diclofenac gel has been put into the market by Ciba-Ceigy Company. It is reported that due to its good transdermal absorption, local or systemic inflammation and pain can be relieved more rapidly, and because it is a dermatological drug, it can exert a more sustained therapeutic effect while avoiding gastrointestinal irritation. In China, the Institute of Pharmaceutical Industry, Shandong Province, developed Diclofenac gel ointment, the paper reported its anti-inflammatory analgesic effect of the study.