复合型口服避孕药可引起血栓栓塞、高血压等严重副作用,许多不良反应继发于肝功能的改变且至少与雌激素的摄入量有部分关系。但是,用含d-18甲基炔诺酮与雌二醇的阴道避孕环能抑制排卵,却不引起肝功能紊乱。估计由阴道吸收的雌激素在到达肝脏以前已分布到全身,立即被结合到主要靶器官的受体上,因此,作用于肝细胞的分子减少。本工作经阴道给予乙炔雌二醇(E.E),了解避免 Compound oral contraceptives can cause serious side effects such as thromboembolism, high blood pressure, many of the adverse reactions secondary to changes in liver function and at least some of the estrogen intake. However, vaginal contraceptive rings containing d-18 methyl norethindrone and estradiol suppressed ovulation without causing liver dysfunction. Estrogen, which is estimated to be absorbed by the vagina, is distributed throughout the body before it reaches the liver and is immediately bound to the receptors of the major target organs, thereby decreasing the number of molecules that act on the hepatocytes. This work transvaginally administered ethinyl estradiol (E. E), to understand and avoid