近年来,我们开拓了苯骈三氮唑(HBT)双活性酰胺的选择性N-酰基化及O-酰基化反应,并成功地用于合成聚酰胺,聚酯,具有规整结构的半硬链聚(酰胺-酯)及具有核酸碱基衍生物作为悬挂基的半硬链聚酯。作为我们研究计划的继续,我们进一步发展这两个反应用在合成一种新类型的聚酯核酸类似物,即合成含有脲嘧啶及胸腺嘧啶衍生物为悬挂侧基的柔顺链聚酯。 In recent years, we have pioneered the selective N-acylation and O-acylation of the bifunctional amides of benzotriazole (HBT) and have been successfully used in the synthesis of polyamides, polyesters, semi-hard chains with regular structure Poly (amide-ester), and semi-hard chain polyesters having a nucleic acid base derivative as a pendant group. As a continuation of our research project, we further developed these two reactions for the synthesis of a new class of polyester nucleic acid analogs, namely, the synthesis of a soft-chain polyester containing uracil and thymine derivatives as pendent pendent groups.