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人工麝香为代替中药麝香的原料药，属中药Ⅰ类新药。本研究对其致突变性进行评价。当人工麝香的剂量为１８００、７００和３５０ｍｇ／ｋｇ时，昆明种小鼠骨髓嗜多染细胞的微核率分别为２．８‰、１．３‰和１．０‰；当人工麝香浓度为６２５、１２５０、２５００和５０００μｇ／皿时，无论加或不加Ｓ９混合物对ＴＡ９７、ＴＡ９８、ＴＡ１００和ＴＡ１０２菌株的回复突变作用均为阴性。当人工麝香剂量为３６０、１８０和９０ｍｇ／ｋｇ时，小鼠骨髓染色体畸变率分别为１．０％、０．８％和１．２％。上述结果表明，人工麝香没有致突变作用。
Artificial musk is a raw material medicine that substitutes for traditional Chinese medicine musk. It is a new type I Chinese medicine. This study evaluated its mutagenicity. When the dose of artificial musk was 1800, 700 and 350 mg/kg, the micronucleus rate of bone marrow hyperchromatic cells in Kunming mice was 2.8 ‰, 1.3 ‰ and 1.0 分别, respectively; when the artificial musk concentration was At 625, 1250, 2500, and 5000 μg/dish, reversal of TA97, TA98, TA100, and TA102 strains was negative with or without the S9 mixture. When the dose of artificial musk was 360, 180 and 90 mg/kg, the chromosome aberration rate of mouse bone marrow was 1.0%, 0.8% and 1.2%, respectively. The above results show that artificial musk has no mutagenic effect.