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目前对初治排菌的肺结核病人,经合理化疗后痰菌阴转率达95-100％,远期复发率低于5％.但仍有部分病人,因不规则用药或疗程不足使化疗失败.1980年crofton指出化疗失败的主要原因在于病人不合作,不能坚持服药到底.第三世界国家不合理用药的病例占50％左右,即使工业发达的美国也有27％的病人不能按规定用药.这种复治病例对目前抗结核药物均呈耐药,治疗十分困难,不但导致病人死亡,并构成在社会上的危险传染源.因此,亟待新药以解决此类病人的治疗问题.
At present, the tuberculosis patients with newly diagnosed bacteriuria have a negative conversion rate of 95-100% and a long-term recurrence rate of less than 5% after rational chemotherapy, but some patients still fail chemotherapy due to irregular medication or inadequate treatment In 1980, crofton pointed out that the main reason for the failure of chemotherapy is that the patients are not cooperative and can not persist in taking drugs, and about half of the irrational drug use in third world countries is even impossible in the industrialized United States, where 27% of patients can not be prescribed. Rehabilitation cases are currently resistant to the current anti-TB drugs, and treatment is very difficult, which not only leads to the death of patients but also constitutes a dangerous source of infection in society. Therefore, new drugs are urgently needed to solve the treatment problems of such patients.