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目的探讨血清对氧磷酶1活性与慢性胰腺炎发病的关系。方法 152例慢性胰腺炎患者(观察组)和128例体检健康者(对照组),采用分光光度法检测血清对氧磷酶1活性,并进行2组间比较。结果观察组血清对氧磷酶1活性((412.56±135.86)u/mL)明显低于对照组((582.74±176.37)u/mL)(P<0.01);多因素logistic回归分析结果显示,血清对氧磷酶1活性降低是慢性胰腺炎发病的独立危险因子。结论血清对氧磷酶1可作为预测慢性胰腺炎发病的一项血清学标志物。
Objective To investigate the relationship between serum paraoxonase 1 activity and the pathogenesis of chronic pancreatitis. Methods 152 patients with chronic pancreatitis (observation group) and 128 healthy subjects (control group) were enrolled in this study. Serum paraoxonase 1 activity was measured by spectrophotometry and compared between the two groups. Results The serum paraoxonase 1 activity in the observation group was significantly lower than that in the control group (412.56 ± 135.86 u / mL vs 582.74 ± 176.37 u / mL, P <0.01). The multivariate logistic regression analysis showed that serum Decreased activity of paraoxonase 1 is an independent risk factor for chronic pancreatitis. Conclusion Serum paraoxonase 1 can be used as a serological marker in predicting the incidence of chronic pancreatitis.