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采用镉还原和Ｇｒｉｅｓｓ反应法，测定１６例原发性单纯性肾病综合征（ＩＮＳ）、２０例急性肾小球肾炎（ＡＧＮ）和２６例过敏性紫＊（ＨＳＰ）病儿血清中一氧化氮（ＮＯ）的稳定代谢产物ＮＯ２＋ＮＯ３浓度。结果发现三种肾小球疾病病儿血清ＮＯ与５２例健康儿童比较分别有不同程度变化；ＩＮＳ活动期较ＡＧＮ急性期显著增高；ＨＳＰ中有肾损害表现病儿明显高于无肾损害表现病儿．本研究提示，血清ＮＯ水平变化与肾小球疾病的不同病因及病理损伤有关；测定血清ＮＯ可能有助于鉴别ＩＮＳ与ＡＧＮ以及其它炎症性肾小球疾病，可能对判断ＨＳＰ的病情严重程度及指导治疗有一定参考价值。
The serum levels of nitric oxide (NO) in 16 children with idiopathic simple nephrotic syndrome (INS), 20 with acute glomerulonephritis (AGN) and 26 with allergic purple (HSP) were determined by cadmium reduction and Griess reaction. (NO), a stable metabolite NO2 + NO3 concentration. The results showed that three kinds of glomerular disease serum NO and 52 cases of healthy children, respectively, compared with varying degrees of change; INS activity was significantly higher than the AGN acute phase; HSP in children with renal damage was significantly higher than the performance of children without renal damage child. This study suggests that serum NO levels and glomerular disease of different etiologies and pathological damage related to the determination of serum NO may be helpful in the identification of INS and AGN and other inflammatory glomerular diseases may determine the severity of the HSP and Guiding treatment has a certain reference value.