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选择已开展TB/HIV双重感染防治工作的三个县(区),通过定性研究和关键知情人深入访谈的方法,了解中国TB/HIV双重感染患者治疗过程中药物不良反应监测处理效果并进一步完善机制;评价患者服药依从性的效果和探索有效措施。研究发现,各机构负责不良反应监测处理,医生主动监测优于患者自我监测,监测项目和范围有限、患者吸毒行为、流动性大等不能保证监测处理效果。同时,药物的不良反应、患者经济困难、吸毒行为、艾滋病的社会歧视等都导致患者治疗依从性下降。目前对于药物不良反应的监测处理需加强机构间沟通和参与,加强主动监测方式,扩大不良反应筛查项目和范围等。加强治疗初期督导、采取减免医药费用等使用提醒方式等可以提高患者服药依从性。
Three counties (districts) that have carried out TB / HIV dual infection prevention and control work were selected to understand and further improve the ADR monitoring and treatment effect in the treatment of TB / HIV in China through qualitative research and in-depth interviews with key insiders Mechanism; evaluation of patient compliance and explore effective measures. The study found that agencies responsible for the monitoring and treatment of adverse reactions, doctors take the initiative to monitor better than the patient self-monitoring, monitoring of the project and the limited scope of drug abuse behavior, mobility and other large can not guarantee the monitoring and treatment effect. At the same time, adverse drug reactions, patients’ financial difficulties, drug abuse behaviors and HIV / AIDS social discrimination all lead to a decrease in patient compliance. The current monitoring and treatment of adverse drug reactions need to strengthen inter-agency communication and participation, strengthen the active monitoring methods, and expand the scope of adverse reaction screening projects and so on. To strengthen the initial supervision of treatment, to take relief and other medical expenses remind the use of methods can improve patient compliance.