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在对 6 7例壶腹周围癌患者回顾性调查的基础上 ,采用 Feulgen′s染色方法和自动图像技术 ,定量测定了癌细胞核 DNA含量。结果 :(1) DNA非整倍体在壶腹周围癌中的发生率为 71.6 4 % ,且其发生率随组织学分级而上升 ;非整倍体肿瘤的预后远不如整倍体肿瘤 (P <0 .0 5) ;(2 )生存期≥ 3年和 <3年组的 DNA指数均值 (DI)有显著性差异 (P <0 .0 1) ;(3)按患者 DNA主干系峰位的 DNA指数值分为三种峰型 ,I型峰预后最好 , 型峰最差。提示 :DNA含量变化与组织学分级有密切关系 ,可作为壶腹周围癌常规临床病理的补充 ;非整倍体和 DNA指数 >3预示壶腹周围癌预后不良 ;DNA含量测定有助于判断预后 ,筛选高危复发转移病人 ,指导临床治疗。
Based on a retrospective study of 67 patients with periampullary carcinoma, Feulgen’s staining and automatic imaging techniques were used to quantitatively determine the nuclear DNA content of cancer cells. RESULTS: (1) The incidence of DNA aneuploidy in periampullary cancer was 71.64%, and its incidence increased with histological grade; the prognosis of aneuploid tumors was far less than that of ploidy tumors (P <0. 0 5); (2) There was a significant difference in the mean value of the DNA index (DI) between the survival periods ≥ 3 years and <3 years (P < 0.01); (3) Peak position of the DNA in the patient’s main body. The value of the DNA index is divided into three peak types, with the I-type peak having the best prognosis and the type-type peak being the worst. Tip: DNA content changes are closely related to histological grade, and can be used as routine clinical pathological complement of periampullary cancer; aneuploidy and DNA index> 3 predicts poor prognosis of periampullary carcinoma; DNA content determination can help determine the prognosis Screen high-risk patients with recurrence and metastasis to guide clinical treatment.