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目的:研究免疫介导过程对增生性糖尿病性视网膜病变(proliferative diabetic retinopathy PDR)的发生发展的潜在作用。方法:应用特异性的抗辅助T淋巴细胞(CD4)、抗白细胞介素-2(interleukin-2 IL-2)及其受体的单克隆抗体(interleukin-2 receptor IL-2R),对经扁平部玻璃体切割术获得的15例PDR视网膜前膜标本进行了研究。结果:在15例标本中,12例(80%)呈CD4阳性;12例(80%)发现有IL-2,且其中11例也呈CD4阳性;10例(67%)发现有IL-2R,其中9例呈CD4阳性并有释放的IL-2。大多数IL-2R阳性的前膜都来自Ⅰ型糖尿病患者,其中40%的患者小于40岁。结论:研究证实了半数以上的糖尿病视网膜前膜中有激活的免疫细胞和释放的淋巴因子,揭示了免疫反应过程和淋巴因子的生物效应对PDR视网膜前膜的形成起重要作用,尤其在青年患者和Ⅰ型糖尿病患者。眼科学报1999;15:229-232。
Objective: To investigate the potential role of immune-mediated process in the development of proliferative diabetic retinopathy (PDR). Methods: By using specific anti-helper T lymphocytes (CD4), anti-interleukin-2 IL-2 and interleukin-2 receptor IL-2R, 15 cases of PDR retinal pre-membrane specimens obtained by vitrectomy were studied. RESULTS: Of the 15 specimens, 12 were positive for CD4 (80%), IL-2 was found in 12 (80%), and 11 were also positive for CD4; 10 (67%) were found to have IL-2R , Of which 9 were CD4 positive and released IL-2. Most of the IL-2R-positive pre-membranes are from Type I diabetic patients, 40% of whom are less than 40 years of age. CONCLUSIONS: Studies confirm that more than half of pre-diabetic retinal membranes have activated immune cells and released lymphokines, revealing that the immune response process and the biological effects of lymphokines play an important role in PDR formation, particularly in young patients And type I diabetes. Journal of Ophthalmology 1999; 15: 229-232.