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[目的]研究γ-连环素在大鼠舌部鳞状细胞癌中的表达,探讨其在口腔鳞状细胞癌癌变过程中的作用.[方法]免疫组织化学方法检测48例不同分化程度大鼠舌部鳞状细胞癌中γ-连环素的表达.[结果]γ-连环素在大鼠舌黏膜癌变过程中均有表达,表达部位在细胞膜,γ-连环素的表达与大鼠舌黏膜癌变过程中的组织学分级不具有显著性差异(P>0.05).[结论]γ-连环素在大鼠舌黏膜癌变中具有一定作用.
[Objective] To investigate the expression of γ-catenin in rat tongue squamous cell carcinoma and its role in the carcinogenesis of oral squamous cell carcinoma. [Methods] Immunohistochemistry was used to detect 48 differentiated rats Γ-catenin expression in tongue squamous cell carcinoma. [Results] γ-catenin was expressed in the carcinogenesis of tongue mucosa in rats, the expression of the expression site in the cell membrane, γ-catenin and tongue carcinogenesis There was no significant difference in histological grading between the two groups (P> 0.05). [Conclusion] γ-Catenin plays a role in carcinogenesis of tongue mucosa in rats.