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目的探讨奥美拉唑加两种抗生素采用不同方案治疗幽门螺杆菌(Hp)感染以及Hp相关性活动期十二指肠溃疡(DU)的治疗效果。方法对52例经快速尿素酶试验及病理学Giemsa染色法检查Hp均为阳性的活动期DU患者,给予奥美拉唑20 mg、阿莫西林1000 mg,呋喃唑酮100 mg。一周治疗组(A组):2次/d,饭前1 h口服,共1周;四周治疗组(B组):2次/d,饭前1 h服用,共4周。疗程结束4周及1年对两组病人经快速尿素酶试验及病理学Giemsa染色法检查Hp。结果疗程结束后4周及1年,两组溃疡治愈率及幽门螺杆菌根除率相比较,差异无统计学意义,而两组毒副作用发生率(分别为7.7%、26.0%)相比较,差异有统计学意义(P<0.05)。Hp根除组与Hp未根除组溃疡治愈率(分别为96.1%、56.0%)相比较;差异有统计学意义(P<0.05)。结论由奥美拉唑、阿莫西林、呋喃唑酮三联一周疗法治疗Hp相关性活动期DU,Hp根除率高,毒副作用少,疗程短,患者依从性好,且价廉、安全、实用,值得在临床上推广应用。
Objective To investigate the therapeutic effects of omeprazole plus two antibiotics in treating Hp infection and Hp-related duodenal ulcer (DU) with different regimens. Methods Fifty-two active Duchenne patients with positive Hp were examined by rapid urease test and pathological Giemsa staining. The patients were given omeprazole 20 mg, amoxicillin 1000 mg and furazolidone 100 mg. One week treatment group (group A): 2 times / d, oral 1 h before meals for 1 week; four weeks treatment group (B group): 2 times / d, taking 1 h before meals for 4 weeks. Four weeks and one year after the end of treatment, two groups of patients were examined by rapid urease test and pathological Giemsa staining. Results Four weeks and one year after the end of treatment, the ulcer cure rates and eradication rates of Helicobacter pylori in the two groups had no significant difference, but the incidence of side effects in the two groups were 7.7% and 26.0% respectively There was statistical significance (P <0.05). Hp eradication group and Hp eradication group ulcer cure rate (96.1%, 56.0%, respectively) compared; the difference was statistically significant (P <0.05). Conclusions The triple therapy of omeprazole, amoxicillin and furazolidone in one-week treatment of Hp-related active stage DU has high Hp eradication rate, few toxic and side effects, short course of treatment, good compliance, low cost, safety and practicability Clinical application.