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目的观察新一代质子泵抑制剂潘托拉唑针剂预防中重度急性卒中应激性溃疡出血的疗效。方法分二阶段分别用国产潘托拉唑针剂60 mg+0.9%生理盐水微泵静推,每12小时一次,疗程5~7 d,或合资奥美拉唑针剂40 mg+0.9%生理盐水微泵静推,每12小时一次,疗程5~7 d,治疗中重度急性卒中的住院病人,进行前后对照研究,观察患者消化道出血情况,并检验大便隐血。结果共66例患者纳入研究,实验组35例,对照组31例,有5例病人发生出血,均为重度患者,其中实验组3例(8.57%),对照组2例(6.45%),两组比较,P=1.000。且明显低于文献的20.56%。结论国产的潘托拉唑针和合资的奥美拉唑疗效相近,差异无统计学意义。潘托拉唑针适于中重度急性卒中应激性溃疡出血的预防。
Objective To observe the effect of a new generation of proton pump inhibitor Pantoprazole on the prevention of acute exacerbation of acute stroke-induced ulcer bleeding. Methods The patients were treated with domestic pantoprazole 60 mg + 0.9% saline micro-pump in two phases, once every 12 hours for 5-7 days, or 40 mg 0.9% saline omeprazole Pump every 12 hours, a course of treatment of 5 ~ 7 d, the treatment of patients with severe acute stroke inpatients, compared before and after the study to observe the situation of patients with gastrointestinal bleeding, and test stool occult blood. Results A total of 66 patients were enrolled in the study. There were 35 cases in the experimental group and 31 cases in the control group. Bleeding occurred in 5 patients, all of whom were severe patients. Among them, 3 cases (8.57%) in the experimental group and 2 cases (6.45%) in the control group Group comparison, P = 1.000. Which is obviously lower than 20.56% of the literature. Conclusion Domestic pantoprazole needle and omeprazole joint effects of similar, the difference was not statistically significant. Pantoprazole Acupuncture is Suitable for Prevention of Hemorrhagic Stress Ulcer in Severe Acute Stroke.