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目的探讨针刺联合化疗对乳腺癌疗效的影响。方法将48例拟行新辅助化疗的乳腺癌患者随机分为治疗组和对照组各24例。治疗组采用化疗联合针刺治疗的方法进行3周期的治疗,而对照组单纯行3周期化疗,每周期评价化疗不良事件,并在治疗第63天评估治疗效果。结果治疗组完全缓解(CR)2例,部分缓解(PR)14例,有效率(CR+PR)67%(16/24);对照组完全缓解(CR)1例,部分缓解(PR)10例,有效率(CR+PR)50%(11/22)。2组有效率比较无显著性差异。针刺联合化疗组的粒细胞下降发生率及呕吐发生率显著低于单纯化疗组;2组间的血红蛋白下降率、血小板下降率、便秘发生率、口腔炎发生率及转氨酶升高率未见显著性差异。结论针刺联合新辅助化疗能有效降低化疗的不良反应,但未能有效提高乳腺癌的治疗有效率。
Objective To investigate the effect of acupuncture combined with chemotherapy on the efficacy of breast cancer. Methods Forty-eight patients with breast cancer who underwent neoadjuvant chemotherapy were randomly divided into treatment group (24 cases) and control group (24 cases). The treatment group was treated with chemotherapy combined with acupuncture for 3 cycles, while the control group was treated with 3 cycles of chemotherapy alone. The chemotherapy adverse events were evaluated every cycle, and the treatment effect was evaluated on the 63rd day of treatment. Results In the treatment group, there were 2 cases of complete remission (CR), 14 cases of partial remission (PR) and 67% (16/24) of effective rate. The control group received complete remission (CR) Cases, effective (CR + PR) 50% (11/22). There was no significant difference between the two groups in the efficiency. The incidence of neutropenia and vomiting in acupuncture combined with chemotherapy group were significantly lower than those in chemotherapy alone group. There was no significant difference between the two groups in the rate of hemoglobin decline, the rate of platelet decline, the incidence of constipation, the incidence of stomatitis and the rate of transaminase Sex differences. Conclusion Acupuncture combined with neoadjuvant chemotherapy can effectively reduce the adverse reactions of chemotherapy, but failed to effectively improve the treatment of breast cancer.