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52例心肌炎患儿随机分为抗氧化剂(VE、VC、CO—Q_(10))治疗组和能量合剂(ATP、CO-A)对照组。治疗前两组血清LPO浓度均高于正常组和上感组,RBC溶血%亦高于正常组,LPO浓度与RBC溶血%呈轻度正相关,与LDH活性呈中度正相关。一疗程治疗后,治疗组LPO浓度及RBC溶血%均下降至正常水平,临床症状体征及EKG改变都恢复较快,心肌酶GOF、LDH活性下降也较显著;对照组LPO浓度虽有所下降,但仍高于正常组,RBC溶血%治疗前后差別则无显著性。提示脂质过氧化损伤与心肌炎发病有一定关系,抗氧化剂治疗有助于疾病较快恢复。
Fifty-two children with myocarditis were randomly divided into the treatment group of antioxidant (VE, VC, CO-Q_ (10)) and the control group of energy (ATP, CO-A) Serum LPO concentrations in the two groups before treatment were significantly higher than those in the normal group and the upper sensory group. The hemolysis% of RBC was also higher than that of the normal group. The LPO concentration was slightly positively correlated with the RBC hemolysis, and positively correlated with the LDH activity. After a course of treatment, LPO concentration and RBC hemolysis% of the treatment group decreased to normal levels, clinical symptoms and signs and EKG changes recovered quickly, and myocardial enzyme GOF, LDH activity decreased significantly; LPO concentration in the control group decreased, But still higher than the normal group, RBC hemolysis before and after treatment was no significant difference. Tip lipid peroxidation damage and the pathogenesis of myocarditis have a certain relationship, anti-oxidant treatment helps to recover the disease faster.