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目的探讨介入检查和治疗过程中水化联合小剂量多巴胺对对比剂肾病的预防作用。资料与方法选择140例于2008年3月至2008年9月接受冠状动脉造影检查或治疗的患者,将其随机分为水化联合小剂量多巴胺研究组和水化治疗对照组。在水化治疗的基础上,研究组同时给予小剂量多巴胺(2μg·kg-1·min-1)。检测所有患者术前、术后第2天、第3天血清肌酐(Crea)水平。结果研究组有3例(4.29%)发生对比剂肾病,对照组有11例(15.7%)。两组比较差异有统计学意义(P<0.05)。结论与单纯水化治疗相比,水化联合小剂量多巴胺可更显著地减少对比剂对肾功能的损害,对对比剂肾病的发生有一定的预防保护作用。
Objective To investigate the preventive effect of low-dose hydration combined with dopamine on contrast-induced nephropathy during interventional examination and treatment. Materials and Methods 140 patients undergoing coronary angiography or treatment from March 2008 to September 2008 were randomly divided into hydration combined with low-dose dopamine group and hydration control group. On the basis of hydration therapy, the study group also given a small dose of dopamine (2μg · kg-1 · min-1). Serum creatinine (Crea) levels were measured in all patients preoperatively and on the 2nd and 3rd postoperative day. RESULTS: Three (4.29%) patients developed contrast-induced nephropathy in the study group and 11 (15.7%) in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Compared with simple hydration therapy, hydration combined with low dose of dopamine can significantly reduce the contrast agent on renal function damage, the occurrence of contrast agent nephropathy have some preventive and protective effect.