肝纤维化是所有慢性肝病向肝硬化发展的必经病理过程，阻止肝纤维化的发生和发展，对于改善慢性肝病患者的预后具有重要意义，因此，肝纤维化的防治研究已成为国内外学者关注的重要课题。肝纤维化的病理特征是细胞外基质（ＥＣＭ）在肝窦周间隙的大量沉积，特别是Ⅰ、Ⅲ型胶原 Liver fibrosis is the pathological process of all chronic liver diseases to the development of cirrhosis and prevent the occurrence and development of liver fibrosis, which is of great significance for improving the prognosis of patients with chronic liver disease. Therefore, the prevention and treatment of liver fibrosis has become a An important topic of concern. The pathological feature of liver fibrosis is the massive deposition of extracellular matrix (ECM) in the peripannal sinusoids, especially type I and type III collagen