下肾單位肾病为多种原因所致的急性继发性腎臟損害的綜合病征,往昔甚少被重视,近十余年来始有进一步的研究,而認为是一独立的疾病。1946年Luke氏曾对538名各种病因所致的急性肾功能不全病例(如战伤、压仿,輸血反应、磺胺中毒等)的尸体解剖进行了研究,發現此类病人的肾臟腫大,外層蒼白,內層充血,鏡下肾小球無特殊改变,但肾小管远端及亨利氏攀上行枝上皮呈普遍性的脂肪变性或局限性坏死,肾小管內常有 Lower nephron nephropathy for a variety of causes of acute kidney injury secondary syndrome, rarely paid attention to the past, more than a decade began to further study, and that is an independent disease. In 1946 Luke’s had 538 cases of acute renal failure caused by various causes (such as war injuries, pressure imitation, transfusion reactions, sulfonamides, etc.) of the autopsy study found that such patients with enlarged kidney , The outer pale, the inner congestion, no special changes in the glomerular microscopy, but the distal tubule and Henri’s climbing on the branches of the epithelium was generally steatosis or localized necrosis, often within the renal tubule