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目的:探讨冠心病患者血管内皮功能障碍及动脉弹性与冠状动脉造影Gensini评分的关系。方法:采用高分辨率血管超声法检测冠心病患者(76例)与正常对照组(30例)肱动脉血流介导的内皮依赖性血管舒张功能(FMD);应用动脉弹性功能检测仪测定受试者的大动脉弹性指数(C1)和小动脉弹性指数(C2);对冠心病患者进行冠状动脉造影,并通过Gensini评分系统对冠心病患者冠状动脉病变进行评分。结果:冠心病组血流介导的FMD明显低于对照组[(6.94±4.21)%:(11.10±4.36)%,P<0.05];冠心病组与对照组的C1差异无统计学意义[(117.0±38.1):(121.1±38.2)ml/mmHg(1mmHg=0.133kPa),P>0.05],但冠心病组的C2明显低于对照组[(516.0±264.0):(626.0±236.0)ml/mmHg,P<0.05],冠心病患者FMD及C2均与冠状动脉造影Gensini评分呈负相关(r=-0.380,P<0.01及r=-0.329,P<0.01)。结论:C2和FMD似可作为评价冠状动脉病变程度的新指标。
Objective: To investigate the relationship between vascular endothelial dysfunction and arterial elasticity in patients with coronary heart disease and coronary angiography Gensini score. Methods: The brachial artery-mediated endothelium-dependent vasodilation (FMD) in coronary artery disease (76 cases) and normal control group (30 cases) was detected by high-resolution vascular ultrasonography. The arterial elasticity function detector The arterial elasticity index (C1) and arterial elasticity index (C2) of the subjects were measured. Coronary angiography was performed on patients with coronary heart disease. Coronary artery disease was evaluated by Gensini scoring system. Results: The blood flow-mediated FMD in coronary heart disease group was significantly lower than that in control group [(6.94 ± 4.21)% (11.10 ± 4.36)%, P <0.05]. There was no significant difference in C1 between coronary heart disease group and control group (117.0 ± 38.1) :( 121.1 ± 38.2) ml / mmHg (1mmHg = 0.133kPa), P> 0.05]. However, the C2 level in the CHD group was significantly lower than that in the control group [(516.0 ± 264.0) :( 626.0 ± 236.0) ml / mmHg, P <0.05]. FMD and C2 in patients with coronary heart disease were negatively correlated with Gensini score of coronary angiography (r = -0.380, P <0.01 and r = -0.329, P <0.01). Conclusion: C2 and FMD can be used as a new index for evaluating the severity of coronary artery disease.