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４５名健康育龄妇女连续服用低剂量口服避孕药９个月后观察服药早期（连续服３个月）、长期服药（连续服９个月）及停药３个月后妇女血浆中主要血凝及纤溶指标的变化，并与服药前的基础值相比较。结果显示：服药早期血小板计数（ＰＬＴ）、凝血因子Ｘ、纤维蛋白原、纤溶酶原显著升高；长期服药后除上述改变外，凝血酶原时间（ＰＴ）和部分凝血活酶时间（ＡＰＴＴ）缩短。提示长期应用低剂量口服避孕药对妇女血凝及纤溶系统具有轻微的影响。
45 healthy women of childbearing age after taking low-dose oral contraceptives 9 months after the early observation of medication (continuous service for 3 months), long-term medication (continuous service for 9 months) and withdrawal of 3 months after the main plasma clotting and Fibrinolysis changes, and compared with the baseline value before taking medicine. The results showed that the platelet count (PLT), coagulation factor X, fibrinogen and plasminogen were significantly increased in the early period of medication. In addition to the above changes, the prothrombin time (PT) and partial thromboplastin time (APTT )shorten. Suggesting that long-term use of low-dose oral contraceptives has a slight effect on the hemagglutination and fibrinolysis system in women.