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目的探讨应用人重组肿瘤坏死因子 (rTNF)联合顺铂 (DDP)治疗癌性胸腔积液的疗效 .方法对 5 0例经病理证实为癌性胸腔积液的患者采用尽量抽净胸水后 ,胸腔内注入rTNF 2 0万U和DDP 40mg ,1次 /d ,连续 2～ 4次 .结果近期完全缓解 (CR)达 90 % ,其中 12例持续 6个月未发现胸水 ,所有病例 2～ 4周后 ,经B超检查均有不同程度的胸膜增厚及粘连 .结论rTNF联合DDP治疗癌性胸腔积液疗效显著 ,单药用量小 ,毒副作用小 .
Objective To investigate the efficacy of recombinant human tumor necrosis factor (rTNF) combined with cisplatin (DDP) in the treatment of malignant pleural effusions.Methods Fifty patients with pathologically confirmed pleural effusions were treated with pleural fluid, Results The immediate complete response (CR) reached 90%, of which 12 cases did not find pleural effusion for 6 months, all cases were 2 to 4 weeks After the B-ultrasound have varying degrees of pleural thickening and adhesions.Conclusion rTNF combined with DDP treatment of malignant pleural effusion significant effect, single-dose, side effects.