我国应用布氏活菌苗给人群预防接种,已有20余年的历史。以前主要是采用皮下接种的方法,由于全身和局部反应都比较重,故不受广大群众欢迎。最近10多年来国内外都在研究新的免疫途径,以提高免疫效果,并已取得一定的成绩。我国用S_2苗饮水免疫和M_5号活菌苗气溶胶免疫,对控制布鲁氏菌病已起了非常重要的作用,但这两种免疫途径能否适用于人群?虽有报道,结果尚不一致。近几年我所对这两种途径和其它免疫途径也进行了探 China’s use of live vaccine against Brachysyzhu vaccination has been more than 20 years of history. Before the main method is the use of subcutaneous inoculation, due to systemic and local reactions are heavier, it is not popular with the masses. In the recent 10 years, both at home and abroad have been studying new immunization routes to enhance the immunization effect and have achieved some success. In our country, S 2 vaccine and M_5 live vaccine aerosol immunization have played a very important role in the control of Brucellosis. However, are the two immunization approaches applicable to the population? Although the results are not consistent . In recent years, I have also explored these two routes and other immunization routes