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目的考察参芪扶正注射液与三种抗肿瘤药物的配伍稳定性。方法在不同时间和温度时观察配伍液的外观、澄明度,并测定配伍液中三种抗肿瘤药物的含量变化。结果与结论参芪扶正注射液穴I雪与三种抗肿瘤药物配伍后,外观、澄明度均无明显变化,含量测定表明,甲氨喋呤穴IV雪配伍液性质稳定,氟尿嘧啶穴II雪配伍液基本稳定,该两药与参芪扶正注射液临床配伍应用是可行的。丝裂霉素穴III雪配伍液在低温时较稳定,随温度升高及贮存时间延长稳定性变差,临床应用时应谨慎配伍。
Objective To investigate the compatibility of Shenqi Fuzheng injection with three anti-tumor drugs. Methods The appearance and clarity of compatibility liquid were observed at different time and temperature, and the contents of three anti-tumor drugs in the compatibility liquid were determined. RESULTS AND CONCLUSIONS: The appearance and clarity of Shenqi Fuzheng Injection Xueya Xue combined with the three anti-tumor drugs showed no significant changes. The determination of content showed that the compatibility of MTX and IV Xuexu was stable, Liquid basically stable, the two drugs and Shenqi Fuzheng injection clinical compatibility application is feasible. MMC mitochondria compatibility compatibility at low temperature more stable, with the temperature and storage stability of prolonged deterioration of clinical application should be cautious compatibility.