AIM:It is difficult to differentiate gallstone dyspepsia andfunctional dyspepsia by clinical symptoms and signs.Wehypothesized that gallstone dyspepsia was related toabnormal gallbladder motility.We aimed to differentiategallstone dyspepsia from functional dyspepsia by measuringgallbladder motility.METHODS:We measured gallbladder volume changes inresponse to gastric distension (saline 500mL) and fatty mealin 10 normal volunteers (controls) and 62 patients withgallstones and dyspepsia before cholecystectomy.Fortycholecystectomized patients were symptom free or hadimprovement (group Ⅰ),while the remaining 22 patients hadpersistent dyspepsia (group Ⅱ).Gallbladder volume changeand ejection fraction were analyzed and compared amongthe three groups.RESULTS:In group Ⅰ,there were significant decreases ingallbladder volumes 5-25 min after gastric distension,compared to fasting volumes.Compared to normal volunteersand group Ⅱ,group Ⅰ had significantly decreased gallbladdervolumes 10-20 min after drinking 500 mL of normal salineand 10 to 50 min after eating fatty meal.CONCLUSION:Our results support the hypothesis thatincreased gallbladder contraction after gastric distension orfatty meal may be related to dyspeptic symptoms inuncomplicated gallstone disease.These findings may beuseful in differentiating functional dyspepsia from gallstonedyspepsia,patients with the latter disease may benefit fromlaparoscopic cholecystectomy. AIM: It is difficult to differentiate gallstone dyspepsia and functional dyspepsia by clinical symptoms and signs. Weypothesized that gallstone dyspepsia was related to abnormal gallbladder motility. We designed to differentiategallstone dyspepsia from functional dyspepsia by measuring gallbladder motility. METHODS: We measured gallbladder volume changes in response to gastric distension (saline 500 mL) and fatty mealin 10 normal volunteers (controls) and 62 patients with gallstones and dyspepsia before cholecystectomy. Fortycholecystectomized patients were symptom free or hadimprovement (group I), while the remaining 22 patients hadpersistent dyspepsia (group II) .Gallbladder volume change and ejection fraction were analyzed and compared among among three groups .RESULTS: In group I, there were significant decreases in gallbladder volumes 5-25 min after gastric distension, compared to fasting volumes.Compared to normal volunteers and group II, group I had significantly decreased gallbladder volumes 10-20 min after drinking 500 mL of normal saline and 10 to 50 min after eating fatty meal. CONCLUSION: Our results support the hypothesis that wascreased gallbladder contraction after gastric distension orfatty meal may be related to dyspeptic symptoms in uncomplicated gallstone disease. The findings may be useful in differentiating functional dyspepsia from gallstonedyspepsia, patients with late latter may benefit fromlaparoscopic cholecystectomy.