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AIM:It is reasonable to assume that microchimerismcould also be involved in the induction of primary biliarycirrhosis (PBC).However,previous reports investigatedonly fetus-microchimerism in women patients.Maternalmicrochimerism has not been investigated until now.The current study aimed to clear either maternalmicrochimerism was involved in the pathogenesis of PBCor not.METHODS:We used fluorescence in situ hybridization onparaffin-embedded tissue (We called“Tissue-FiSH”.) todetermine whether maternal cells infiltrated in malepatients who were diagnosed as having PBC.Tissue-FiSHwas performed by using both X and Y specific probes onthe biopsy liver sample of 3 male PBC patients.RESULTS:Infiltrating lymphocytes demonstrated both Xand Y signals in all 3 male patients.CONCLUSION:Maternal microchimerism dose not play asignificant role in PBC.PBC may not relate to fetus andmaternal microchimerism.
AIM: It is reasonable to assume that microchimerism can also be involved in the induction of primary biliarycirrhosis (PBC) .However, previous reports investigatedonly fetus-microchimerism in women patients. Maternalmicrochimerism has not been called until now. Current current aimed at clear to maternalmicrochimerism was involved in the pathogenesis of PBCor not. METHODS: We used fluorescence in situ hybridization onparaffin-embedded tissue (We called “Tissue-FiSH”.) todetermine whether maternal cells infiltrated in malepatients who were diagnosed as having PBC.Tissue-FiSHwas performed by using both X and Y specific probes on the biopsy liver sample of 3 male PBC patients .RESULTS: Infiltrating lymphocytes demonstrated both X and Y signals in all 3 male patients. CONCLUSION: Maternal microchimerism dose not play asignificant role in PBC. PBC may not relate to fetus andmaternal microchimerism.