目的:制备紫杉醇纳米粒,并对其体外释药性能进行考察。方法:用开环聚合法合成壳聚糖-聚乳酸共聚物,采用纳米沉淀法制备包载紫杉醇的纳米粒,研究纳米粒的包封率和释药性能。结果:纳米粒呈球形,粒径均匀,药物包封率达到93.2%;体外模拟释放表明载药纳米粒的释药速率持续稳定。结论:本实验制备方法简便易行,制备的紫杉醇纳米粒具有明显的缓释作用。 OBJECTIVE: To prepare paclitaxel nanoparticles and investigate its in vitro drug release properties. Methods: Chitosan-polylactic acid copolymer was synthesized by ring-opening polymerization. Paclitaxel-loaded nanoparticles were prepared by nano-precipitation method. The entrapment efficiency and drug release properties of nanoparticles were investigated. Results: The nanoparticles were spherical and the particle size was uniform. The entrapment efficiency of the nanoparticles reached 93.2%. The release in vitro showed that the release rate of drug-loaded nanoparticles was stable. Conclusion: The preparation method of this experiment is simple and easy. The prepared paclitaxel nanoparticles have obvious sustained release effect.