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通过药代动力学研究，观察卵巢癌及胃癌术后应用顺铂腹腔化疗的疗效及其副作用。结果表明，腹水中顺铂最大浓度为周围血中的１８．７５倍，顺铂在腹水和血中的清除半衰期分别为３９．９小时和７０．６小时，腹膜对顺铂的清除率为６．１ｍｌ／ｍｉｎ，机体对顺铂的总清除率为１５．３ｍｌ／ｍｉｎ。尿２４小时顺铂排泄量为用药量的１３．５３％，而门静脉血中顺铂浓度高于周围静脉血２．５倍。提示：顺铂能保持腹腔高药物浓度，提高腹腔化疗疗效，降低全身药物毒性反应。
Through pharmacokinetic studies, the efficacy and side effects of cisplatin intraperitoneal chemotherapy for ovarian cancer and gastric cancer were observed. The results showed that the maximum concentration of cisplatin in ascites was 18.75 times that in peripheral blood, the elimination half-lives of cisplatin in ascites and blood were 39.9 hours and 70.6 hours, respectively. The clearance rate of cisplatin by peritoneum was 6 At 1 ml/min, the total body clearance of cisplatin was 15.3 ml/min. The urinary excretion of cisplatin for 24 hours was 13.53% of the dose, while the concentration of cisplatin in portal vein blood was 2.5 times higher than that of peripheral venous blood. Tip: Cisplatin can maintain a high drug concentration in the abdominal cavity, improve the efficacy of intraperitoneal chemotherapy, and reduce systemic drug toxicity.