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如今,肺癌依然是全球癌症死亡相关的主要原因,相比其它类型肿瘤而言,肺部肿瘤往往会表现出大量的基因组变化,这或许是暴露于烟草烟雾中致癌物的结果,而烟草依然是引发肺癌的主要原因,大约10%的肺部肿瘤都会携带一种名为ATM的基因突变,然而目前在临床中并没有可用药物来治疗ATM突变的肺癌。近日,一项刊登在国际杂志Nature Communications上的研究报告中,来自路德维格癌症研究所的研究人员利用先进的高通量药物筛选技术分析了患者机体的遗传组成如何其对药物的反应,研究者惊人地发现,携带ATM突变的癌细胞对抑制MEK酶类的药物非常敏感。MEK是机体
Today, lung cancer remains the leading cause of cancer death worldwide, with lung tumors often exhibiting a large number of genomic changes compared to other types of tumors, perhaps as a result of exposure to carcinogens in tobacco smoke, which remains About 10% of lung cancers carry a genetic mutation called ATM, the main cause of lung cancer. Currently, however, there are no clinically available drugs to treat ATM-mutated lung cancer. Recently, in a study published in the international journal Nature Communications, researchers from Ludwig Cancer Institute used advanced high-throughput drug screening techniques to analyze how the patient’s body’s genetic makeup responds to medications, The researchers surprisingly found that cancers carrying ATM mutations are very sensitive to drugs that inhibit MEK enzymes. MEK is the body