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目的观察不同剂量阿司匹林治疗老年冠心病的临床疗效。方法选取140例冠心病患者,随机分为A、B、C、D 4组。A组患者给予常规药物治疗,B、C、D组在常规药物治疗基础之上,分别给予75 mg/d、100 mg/d、150 mg/d阿司匹林治疗,共7 d,对4组患者临床疗效进行对比。结果 A组治疗有效率为62.9%,B、C、D组均为94.3%,B、C、D组明显高于A组,差异有统计学意义(P<0.05)。B、C、D组间差异无统计学意义(P>0.05)。B、C、D组治疗后血小板聚集率较治疗前明显降低,差异有统计学意义(P<0.01),B、C、D组间对比,差异无统计学意义(P>0.05)。4组患者在临床治疗期间均未出现明显不良反应。结论 75 mg/d、100 mg/d、150 mg/d阿司匹林均能对冠心病患者产生显著的抗血小板作用,但小剂量的阿司匹林更值得推广应用。
Objective To observe the clinical efficacy of different doses of aspirin in the treatment of elderly patients with coronary heart disease. Methods 140 patients with coronary heart disease were randomly divided into A, B, C and D 4 groups. Patients in group A were given conventional medical therapy. Patients in groups B, C and D were given aspirin 75 mg / d, 100 mg / d and 150 mg / d respectively on the basis of conventional medical therapy for 7 days. The efficacy of contrast. Results The effective rate was 62.9% in group A, 94.3% in group B, C and D, and significantly higher in group B, C and D than in group A (P <0.05). There was no significant difference between B, C and D groups (P> 0.05). The platelet aggregation rate in group B, C and D after treatment was significantly lower than that before treatment, the difference was statistically significant (P <0.01). There was no significant difference between group B, C and D (P> 0.05). All the 4 groups showed no obvious adverse reactions during the clinical treatment. Conclusion Aspirin of 75 mg / d, 100 mg / d and 150 mg / d all can produce significant antiplatelet effect in patients with coronary heart disease, but the low dose of aspirin deserves more application.