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PF1022A来自PF1022发酵肉汤中,PF1022株归属于菌丝体属,Mycelia Steriliu株,分离于植物叶上的微植物丛内。其结构为环状缩酚酸酞,由4l—N甲基亮氨酸,2D—酸乳酸及2D—乳酸构成。 从神经药理学的角度研究了PF1022A的作用机制。PF1022A在浓度低到10~(-13)g/ml时尚可抑制广卅管圆线虫的运动,在10~(-12)-10~(-6)g/ml浓度可麻痹虫体。10~(-12)g/mlPF1022A麻痹虫体的作用,可被γ-氨基丁酸能拮抗剂如木防已毒素和比枯枯灵碱部
PF1022A from PF1022 fermentation broth, PF1022 strain belongs to Mycelia genus, Mycelia Steriliu strain, isolated in plant leaves on the micro-plant clumps. Its structure is a cyclic phenolphthalein, composed of 4l-N methyl leucine, 2D-acid lactic acid and 2D-lactic acid. The mechanism of action of PF1022A was studied from the perspective of neuropharmacology. PF1022A can inhibit the movement of C. elegans at concentrations as low as 10 ~ (-13) g / ml, and could paralyze the worms at the concentration of 10 ~ (-12) -10 ~ (-6) g / ml. 10 ~ (-12) g / mlPF1022A role of paralysis of worms, can be γ-aminobutyric acid antagonists such as wood Fang Toxin and the ratio of the Ministry of blight Ling base