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目的比较雷贝拉唑钠肠溶片与奥美拉唑肠溶胶囊治疗老年反流性食管炎的临床疗效。方法选取2012年8月—2014年8月南城县建昌镇卫生院收治的老年反流性食管炎患者100例,随机分为观察组与对照组,各50例。两组患者均予以西沙比利治疗,观察组患者予以雷贝拉唑钠肠溶片治疗;对照组患者予以奥美拉唑肠溶胶囊治疗。观察两组患者临床疗效、内镜检查疗效及不良反应发生情况。结果观察组患者总有效率、治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论雷贝拉唑钠肠溶片治疗老年反流性食管炎的临床疗效优于奥美拉唑肠溶胶囊,雷贝拉唑钠肠溶片能有效改善患者临床症状,且不良反应少。
Objective To compare the clinical efficacy of rabeprazole sodium enteric-coated tablets and omeprazole enteric-coated capsules in the treatment of senile reflux esophagitis. Methods From August 2012 to August 2014, 100 elderly patients with senile reflux esophagitis admitted to Jianchang town hospital in Nancheng county were randomly divided into observation group and control group, 50 cases each. Both groups were treated with cisapride, the observation group were treated with rabeprazole sodium enteric-coated tablets; the control group patients were treated with omeprazole enteric-coated capsules. The clinical efficacy, endoscopic efficacy and adverse reactions in both groups were observed. Results The total effective rate and the total effective rate in the observation group were significantly higher than those in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion The clinical efficacy of rabeprazole sodium enteric-coated tablets in the treatment of senile reflux reflux esophagitis is better than omeprazole enteric-coated capsules. Rabeprazole sodium enteric-coated tablets can effectively improve the clinical symptoms of patients with less adverse reactions.