钙拮抗剂用于治疗缺血性心脑血管疾病和一些非心血管疾病取得了肯定的效果。它是通过阻止细胞膜钙离子的内流和抑制肌浆网(细胞内钙储库)释放钙离子而产生的药理效应。常用的为异搏停(维拉帕米)硫氮(艹卓)酮(地尔硫(艹卓))和硝苯吡啶三种,它们的生物半寿期、首通代谢和血浆有效浓度各不相同,故用药要个体化。一般一日三次服药,主要在肝脏代谢,肾功能不全者可不减少用量。 Calcium antagonists for the treatment of ischemic cardiovascular disease and some non-cardiovascular disease has achieved certain results. It is through the inhibition of cell membrane calcium influx and inhibition of sarcoplasmic reticulum (intracellular calcium reservoir) release of calcium ions and the resulting pharmacological effects. Commonly used for the verapamil (verapamil) sulfur nitrogen (艹 Zhuo) ketone (diltiazem 艹 Zhuo) and nifedipine three species, their biological half-life, first-pass metabolism and plasma concentrations Not the same, so medication should be individualized. Generally three times a day medication, mainly in the liver metabolism, renal insufficiency may not reduce the dosage.