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目的:观察β2受体激动剂班布特罗治疗高原地区慢性阻塞性肺病(COPD)和高原肺心病疗效;方法:对来自2 200m～3 600m 84例高原COPD和肺心病患者给予班布特罗20mg每日一次口服,疗程为2周,并观察给药前后肺功能及血气分析指标的变化;结果:治疗后,肺功能指标(VC、FEV1.0、PEF、FEF50％)及动脉血气指标(PaO2、PaCO2、SatO2)较治疗前均有明显的改善(P<0.05,P<0.001);结论:班布特罗具有较强的支气管扩张作用,能降低气道反应性,改善通气量,提高血氧分压,改善缺氧,作用时间长,副作用较少,是临床治疗支气管痉挛迅速而有效的较好药物。
OBJECTIVE: To observe the curative effect of Banbuterol, a β2receptor agonist, on patients with chronic obstructive pulmonary disease (COPD) and high altitude pulmonary heart disease in the plateau area.Methods: Eighty-eight patients with COPD and pulmonary heart disease from 2200m ~ 3600m were given bambuterol 20mg orally daily for 2 weeks, and observed before and after administration of lung function and blood gas analysis of indicators changes; Results: After treatment, pulmonary function parameters (VC, FEV1.0, PEF, FEF50%) and arterial blood gas index PaO2, PaCO2, SatO2) were significantly improved compared with those before treatment (P <0.05, P <0.001). Conclusion: Bambuterol has a strong bronchodilator effect that can reduce airway reactivity, improve ventilation and improve Oxygen partial pressure, hypoxia, long duration of action, fewer side effects, is a clinical treatment of bronchial spasm quickly and effectively better drugs.