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调查左氧氟沙星注射液所致的不良反应(ADR)的发生率、临床表现及相关因素,旨在安全合理用药。方法:于2000年10月至2001年9月期间在北京市8所医院,采用多中心、前瞻性方法调查4437例使用左氧氟沙星注射液的住院患者发生ADR的情况,并对其进行统计分析。结果:4437例患者中有143例发生ADR,发生率为3.22％,轻度居多,占58.04％,并归纳总结了ADR的临床表现及相关因素。结论:本次调查中左氧氟沙星注射液ADR发生率较低,且程度较轻。值得注意的是,我们在调查中发现ADR的发生与患者的年龄、用药剂量与疗程、过敏史、合并用药等因素有关。因此,临床医生在选用该药时应考虑上述因素,这样就能避免或减少ADR的发生。
Investigate the incidence of adverse reactions caused by levofloxacin injection (ADR), clinical manifestations and related factors, aimed at safe and rational use of drugs. Methods: From October 2000 to September 2001, 837 hospitals in Beijing were investigated by multinocular and prospective methods for ADR in 4437 hospitalized patients receiving levofloxacin injection and statistical analysis was conducted. Results: ADR occurred in 143 of 4437 patients, with a prevalence of 3.22% and a mild degree, accounting for 58.04%. The clinical manifestations and related factors of ADR were summarized. Conclusion: The incidence of ADR in this survey was lower and to a lesser extent. It is noteworthy that we found in the survey ADR occurred with the patient’s age, dosage and duration of treatment, allergy history, the combination of medication and other factors. Therefore, clinicians should consider the above factors in the selection of the drug, so as to avoid or reduce the occurrence of ADR.