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采用在染色体标本上同时显示ＳＣＥ及Ｇ带带型的方法，对鼻咽癌患者染色体断裂热点与ＳＣＥ高发位点、染色体脆性部位及原癌基因位点之间的相关性进行了分析。结果表明：患者的ＳＣＥ频率、染色体畸变率均显著的高于对照组（Ｐ＜０．０１），患者的染色体断裂点和ＳＣＥ位点都主要分布在染色体的Ａ、Ｂ、Ｃ、Ｄ组和浅带上，且两者所累及的染色体号存在着明显的相关（ｒ＝０．９５７６，Ｐ＜０．０１），患者的１５个断裂热点与ＳＣＥ高发位点的一致率为５３．３３％，与脆性部位的一致率为８０％，与原癌基因位点的一致率为４０％
Using the method of displaying both SCE and G-banding patterns on chromosome specimens, the correlation between chromosome breakage hot spots in patients with nasopharyngeal carcinoma and sites of high incidence of SCE, chromosomal fragile sites and proto-oncogenes was analyzed. The results showed that the SCE frequency and chromosome aberration rate of patients were significantly higher than those of the control group (P <0.01). The chromosomal breakpoints and SCE sites were mainly distributed in chromosomes A, B, C, D and There was a significant correlation between the chromosome numbers involved in the two chromosomes (r = 0.9576, P <0.01). The coincidence rate of 15 hot spots and SCE high incidence sites was 53.33% , Consistent with the fragile site was 80%, consistent with the proto-oncogene site was 40%