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目的了解慢性胃炎患者H.pylori感染及其耐药情况,为临床治疗提供参考。方法慢性胃炎患者胃镜活检标本培养分离H.pylori,对分离的H.pylori采用纸片扩散法进行耐药性检测。结果229例患者分离出97株H.pylori;H.pylori分离阳性率为42.36%(97/229),其中男性分离率为43.79%(67/153),女性分离率为39.47(30/76);92株H.pylori对抗生素的耐药性分别为:甲硝唑8.7%,克拉霉素7.6%,阿莫西林1.1%、呋喃唑酮1.1%,阿奇霉素4.4%,左氧氟沙星0%。结论慢性胃炎患者H.pylori感染率较高,但与性别、年龄无关;慢性胃炎H.pylori对常用抗生素敏感,建议采用左氧氟沙星、阿莫西林、呋喃唑酮进行治疗。
Objective To understand H.pylori infection and drug resistance in patients with chronic gastritis and provide reference for clinical treatment. Methods H.pylori was isolated from gastroscopy biopsy specimens of patients with chronic gastritis, and H.pylori isolates were tested for drug resistance by disk diffusion method. Results 97 H.pylori isolates were isolated from 229 patients. The positive rate of H.pylori isolates was 42.36% (97/229), of which 43.79% (67/153) were male and 39.47 (30/76) were female. The drug resistance of 92 strains of H.pylori to antibiotics were: metronidazole 8.7%, clarithromycin 7.6%, amoxicillin 1.1%, furazolidone 1.1%, azithromycin 4.4% and levofloxacin 0%. Conclusions The incidence of H.pylori infection in patients with chronic gastritis is high, but it is not related to sex and age. Chronic gastritis is sensitive to commonly used antibiotics and levofloxacin, amoxicillin and furazolidone are recommended.