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目的探讨细针穿刺细胞学(FNAC)结合TB-DNA检测诊断淋巴结结核的临床价值。方法随机选择2010年1月至2014年11月诊断为淋巴结结核患者56例,分析其FNAC结合TB-DNA检测阳性结果及细胞学分型。结果 56例淋巴结结核中,细针穿刺确诊结核21例(37.5%),TB-DNA确诊17例(30.3%),FNAC结合TB-DNA检测确诊50例(89.3%),FNAC确诊率低于结合TB-DNA检测,差异有统计学意义(P<0.01,χ~2=20.61)。TB-DNA阳性率在干酪坏死型(37.5%)及混合型(26.8%)高于增殖型(8.9%),差异有统计学意义(P﹤0.01,χ~2=9.96)。结论 FNAC结合TBDNA检测操作简便快捷,可提高淋巴结结核确诊率,值得临床推广应用。
Objective To investigate the clinical value of fine needle aspiration cytology (FNAC) combined with TB-DNA in the diagnosis of lymph node tuberculosis. Methods Fifty-six patients diagnosed as lymph node tuberculosis from January 2010 to November 2014 were randomly selected. The positive results of FNAC combined with TB-DNA test and cytological classification were analyzed. Results Twenty-one cases (37.5%) were confirmed by fine-needle aspiration, 17 cases (30.3%) were diagnosed by TB-DNA, 50 cases (89.3%) were diagnosed by FNAC combined with TB-DNA test. TB-DNA test, the difference was statistically significant (P <0.01, χ ~ 2 = 20.61). The positive rates of TB-DNA were higher in cases of necrosis (37.5%) and mixed (26.8%) than in proliferative (8.9%), the difference was statistically significant (P <0.01, χ ~ 2 = 9.96). Conclusion FNAC combined with TBDNA detection is simple and quick, which can improve the diagnosis rate of lymph node tuberculosis and is worthy of clinical application.