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早期自然流产是产科常见的病理性妊娠之一,病因复杂,发病机制仍不明确。生殖免疫学认为,自然流产是母胎之间免疫平衡失调,母体对胎儿组织产生免疫排斥反应的结果。Toll样受体4(TLR4)是天然免疫系统中一类重要的模式识别受体,TLR4信号转导通路激活核因子-κB(NF-κB),使母胎界面绒毛组织发生某些病理改变,打破原有的免疫平衡,引起流产。因此,TLR4-NF-κB通路可能在早期自然流产发生发展中起重要作用。综述TLR4-NF-κB通路与早期自然流产的关系。
Early spontaneous abortion is one of the common obstetric pathological pregnancy, the etiology is complex, the pathogenesis is still not clear. Reproductive immunology that spontaneous abortion is the imbalance between the immune balance between mothers and fetuses, maternal fetal immune rejection reaction results. Toll-like receptor 4 (TLR4) is an important type of pattern recognition receptor in innate immune system. TLR4 signal transduction pathway activates nuclear factor-κB (NF-κB) and causes certain pathological changes in the villi of the maternal-fetal interface and breaks down The original immune balance, causing miscarriage. Therefore, TLR4-NF-κB pathway may play an important role in the development of early spontaneous abortion. The relationship between TLR4-NF-κB pathway and early spontaneous abortion