论文部分内容阅读
嗅神经母细胞瘤系发生于鼻腔上部或筛板的罕见的恶性肿瘤，病理组织学诊断较困难。本文报告１１例，采用免疫组化进行ＮＳＥ、ＮＦ、Ｓ－１００、ＧＦＡＰ、ＬＣＡ和Ｋａｒａｔｉｎ抗体联合标记，结果显示：ＮＳＥ阳性率１１／１１，ＮＦ５／１１，Ｓ－１００３／１１；而ＧＡＦＰ、ＬＣＡ和Ｋａｒａｔｉｎ均为阴性；为５例光镜下病理确诊困难者明确了诊断。本组采用手术、放疗或两者综合治疗。１１例中临床随访７例，其中３例于治疗后１年内因颅内广泛侵犯死亡，４例分别已存活３、４、５和１４年。就嗅神经母细胞瘤的诊断、鉴别诊断、生物学特征及治疗进行了讨论。
Olfactory neuroblastoma is a rare malignant tumor that occurs in the upper part of the nasal cavity or in the sieve plate, making pathological diagnosis more difficult. In this paper, 11 cases were reported, and the combination of NSE, NF, S-100, GFAP, LCA and Karatin antibody was detected by immunohistochemistry. The positive rate of NSE was 11/11, NF5 / 11 and S-1003 / LCA and Karatin were negative; 5 cases of pathological diagnosis under the light of clear diagnosis. This group of surgery, radiotherapy or both combined treatment. Among the 11 cases, 7 cases were followed up clinically. Among them, 3 cases died of extensive intracranial invasion within 1 year after treatment, and 4 cases survived 3, 4, 5 and 14 years respectively. On the diagnosis of neuroblastoma, differential diagnosis, biological characteristics and treatment were discussed.