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5-氟脲嘧啶是抗代谢类抗肿瘤药物,其副作用主要是胃肠道反应,而诱发支气管哮喘临床上极罕见,现报告1例。患者女,42岁,1993年1月3日因胸闷、干咳4月余入院。既往无哮喘及药物过敏史。入院查体:T36.2℃、P82次/分,BP16.0/10.7KPa,一般状况差。气管居中,右锁骨中线第3肋间隙以下叩诊浊音,呼吸音消失,语音传导减弱。实验室检查:Hb114g/L,WBC11.1×10~9/L,心肝肾功能正常。胸片提示右侧大量胸腔积液,经CT及纤维支气管镜、胸水病理检查确诊为右肺腺癌,胸膜转移。确诊后
5-fluorouracil is an anti-metabolic anti-tumor drugs, the main side effects of gastrointestinal reactions, and induced bronchial asthma clinically very rare, is reported in 1 case. Female patient, 42 years old, January 3, 1993 due to chest tightness, dry cough more than 4 months admitted to hospital. No past history of asthma and drug allergy. Admission examination: T36.2 ℃, P82 times / min, BP16.0 / 10.7KPa, the general condition is poor. Tracheal center, right subclavian midline 3 intercostal space following percussion dullness, breath sounds disappear, voice conduction weakened. Laboratory tests: Hb114g / L, WBC11.1 × 10 ~ 9 / L, heart, liver and kidney function is normal. A large number of pleural effusion prompted the right chest X-ray, CT and fiberoptic bronchoscopy, pleural effusion pathological examination diagnosed as right lung adenocarcinoma, pleural metastasis. After diagnosis