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目的 :探讨 Lp( a)与脑卒中发病的关系及其遗传特性。方法 :采用 ELISA双抗体夹心法检测 56例脑梗死、1 7例脑出血病人血清 Lp( a) ,并与 38名无心、脑血管病史者对比 ,且比较其子女的 Lp( a)。结果 :所测脑梗死、脑出血组 Lp( a)值分别为 31 7.76± 1 36.1 1和 4 0 5.0± 1 72 .99,均显著高于对照组 2 0 0 .86± 1 51 .57( P<0 .0 0 1 ) ;Lp( a)≥ 30 0 mg/L的例数也明显超过对照组 ,分别为 31、9和 1 2例。脑梗死患者之子女 Lp( a)显著高于对照组子女。结论 :脑卒中患者血清 Lp( a)显著高于非心、脑血管病者 ;脑梗死者子女血清 Lp( a)也明显高于对照组子女 ,有遗传倾向。
Objective: To investigate the relationship between Lp (a) and the incidence of stroke and its genetic characteristics. Methods: Serum Lp (a) in 56 patients with cerebral infarction and in 17 patients with intracerebral hemorrhage was detected by double antibody sandwich ELISA. The Lp (a) was compared with those without heart and cerebrovascular disease in 38 children. Results: The values of Lp (a) in cerebral infarction and cerebral hemorrhage were 31 7.76 ± 1 36.1 1 and 4.05 ± 1.72. 99, respectively, which were significantly higher than those of the control group 2 0 0 .86 ± 1 51 .57 ( P <0.01). The number of Lp (a)> 30 0 mg / L was also significantly higher than that of the control group (31, 9 and 12, respectively). Children with cerebral infarction Lp (a) was significantly higher than the control group children. Conclusion: Serum Lp (a) in patients with stroke is significantly higher than those in non-cardiac and cerebrovascular patients. Serum Lp (a) in children with cerebral infarction is also significantly higher than that in the control group, with a genetic predisposition.