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目的:分析32例合用多种西药导致临床严重不良反应情况,以提高西药临床合理用药水平。方法:资料回顾性分析2012年12月-2013年12月本院因合用多种西药导致严重不良反应患者32例,观察本组患者合用西药的严重不良反应发生情况,不同西药类型的合用药品种类及构成情况,不同给药方式发生不良反应情况。结果:本组患者用药严重不良反应在皮肤和其附件、消化系统、神经系统等方面均有发生;抗感染药物的药品种类及构成情况与消化系统及心血管系统药物比较,具统计学意义(P<0.05);静脉注射给药不良反应发生率53.13%比肌肉注射给药21.89%,口服给药15.63%,外用局部给药9.38%多,具统计学意义(P<0.05)。结论:医院相关部门应加强监测多种西药合用,避免不合理应用造成的严重不良反应。
OBJECTIVE: To analyze the clinical serious adverse reactions caused by 32 western medicines in combination with western medicine in order to improve the clinical reasonable medication level of western medicine. Methods: Data were retrospectively analyzed from December 2012 to December 2013 in our hospital due to the combination of a variety of western medicine lead to serious adverse reactions in 32 patients, observed in this group of patients with serious adverse reactions Western medicine combined with different types of drugs of Western types And constitute a situation, different modes of administration of adverse reactions. Results: The serious adverse reactions of the patients in this group occurred in the skin and its appendages, digestive system and nervous system. The types and composition of the anti-infective drugs were statistically significant compared with the digestive system and the cardiovascular system drugs P <0.05). The incidence of adverse reactions in intravenous administration was 53.13%, 21.89% more than that in intramuscular injection, 15.63% in oral administration and 9.38% in topical administration, with statistical significance (P <0.05). Conclusion: The hospital departments should strengthen the monitoring of a variety of western medicine to avoid serious adverse reactions caused by unreasonable use.