干燥综合征(SS)是一种以侵及泪腺和唾液腺等外分泌腺为特征的全身性自身免疫病。该病最常见的临床表现为眼干、口干,并可累及肺、肾脏、淋巴系统、血管及肝脏等器官。但其发病机制尚不清楚。有研究发现分布于泪腺、唾液腺及平滑肌的毒蕈碱3(M 3)受体与干燥综合征的发生有着密切 Sjogren’s syndrome (SS) is a systemic autoimmune disease characterized by exocrine glands that invade the lacrimal and salivary glands. The most common clinical manifestations of the disease are dry eyes, dry mouth, and can affect the lungs, kidneys, lymphatic system, blood vessels and liver and other organs. But its pathogenesis is not clear. Studies have found that the muscarinic 3 (M 3) receptors distributed in lacrimal gland, salivary gland and smooth muscle are closely related to Sjogren’s syndrome